플라스틱 가소제인 phthalate에 대한 경피 흡수 특성 연구
김낙주1,†·오은하2·서한슬2·정광보3·윤철훈4
1서울과학기술대학교 자연생명과학대학 정밀화학과, 2(재)네오딘의학연구소,
3한서대학교 공학부 화학공학과, 4대진대학교 화학공학과,

Characteristics of Percutaneous Absorption of Phthalate as Plasticizer
Nack-Joo, Kim1,†, Eun-ha, Oh2, Han-Seul, Suh2, Kwang-Bo, Chung3, and Cheol-Hun Yoon4
1Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul 139-743, Korea
2NEODIN Medical Institute, Seoul 133-170, Korea
3Department of Chemical Engineering, Hanseo Univ., Seosan 356-706, Korea
4Department. of chemical Engineering, University of DeaJin, Pocheon 487-711, Korea
Received February 15, 2013/Revised February 28, 2013/Accepted March 11, 2013

Phthalate is used in a wide range of consumer goods. It has been the subject of great public concern in recent
years. It has attracted the attention of extensive uses of this material and issues regarding its safety have been
raised. Phthalate is currently used through direct addition in cosmetic products and indirectly in fragrances. The
material is listed in the inventory of ingredients employed as a solvent and vehicle in fragrance and cosmetic
products, as well as a plasticizer, denaturant, and film former. In this study, using in vitro from Rat phthalate
3 types of skin permeation were studied using matrix such as ointment, cream and lotion in vitro. The absorption
of phthalate diesters [Butyl benzyl Phthalate (BBP), dibutyl phthalate (DBP) and Diisobutyl Phthalate
(DIBP)] has been measured in vitro through rat skin. Epidermal membranes were set up in Franz diffusion cells
and their permeability to PBS measured to establish the integrity of the skin before the phthalate were applied
to the epidermal surface. Absorption rates for each phthalate ester were determined and permeability assessment
made to quantify any irreversible alterations in barrier function due to contact with the esters. Types of
phthalate in vitro experimental results on DBP > DIBP > BBP quickly appeared in the following order: skin
permeation was beneficial to the skin permeation small molecular weight, the difference in chemical structure,
such as hydrophilic, because with the partition coefficient and solubility mechanisms and passive diffusion to
increase the speed at which transmission is considered. As the esters became more lipophilic and less hydrophilic,
the rate of absorption was reduced.

Key words: Plasticizer, Phthalate, Percutaneous absorption, Skin permeation rate, in vitro